Download Citation | On Dec 31, 2000, Clare M. Isacke and others published P-Selectin | Find, read and cite all the research you need on ResearchGate
This together with minor differences in fucose binding, accounts for the 10-fold higher affinity of E-selectin for SLe x as compared to P-selectin. However, although P-selectin binds SLe x only with millimolar affinity (K D = 7.8 mM), very high affinities are obtained for specific glycoprotein counterreceptors (800 nM for SLe x-modified PSGL-1).
5. 1 0. 1 5. 16HBE only. F lu x. (%.
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8 When stimulated, P-selectin is translocated and up-regulated immediately, initiating the earliest phase of leukocyte recruitment into inflammatory sites. 8 Moreover, this molecule can be regulated transcriptionally by proinflammatory cytokines, such as tumor necrosis factor (TNF)–α. 12,13 E-selectin is not expressed constitutively in normal tissues but is transcriptionally up-regulated by proinflammatory to a lesser extent, E-selectin-mediated binding. Puri- fied P-selectin inhibited CH0:P-selectin binding to HL6O cells, but incompletely inhibited CH0:E-selectin binding to HL60 cells. However, purified soluble E- selectin inhibited CH0:P-selectin and CH0:E-selectin binding to HL60 cells equivalently and completely. This together with minor differences in fucose binding, accounts for the 10-fold higher affinity of E-selectin for SLe x as compared to P-selectin.
or P-selectin expressed by endothelial cells binds to carbohy- drates borne by show here that the binding of E- or P-selectins by specific antibodies induces.
P-selectin are therefore functional under divergent conditions. Similarly to cell-surface P-selectin, E-selectin is rapidly down- regulated by internalization and degradation in lysosomes; however, the intracellular targeting mechanism of E-selectin is still unknown (63,72). Se hela listan på news-medical.net Il ligando della E-selectina è rappresentato da gruppi carboidrati sialilati complessi (sialil-Lewis X) presenti su proteine di superficie dei leucociti.
19 dec. 2020 — Bindningen av PSGL-1 på leukocyten till P-selectin på endotelcellen tillåter Syntes av E-selectin följer strax efter P-selectinsyntes, inducerad av (mikrovaskulatur vs stora fartygsmodeller), flödesförhållanden (t.ex.
selectin: ( sĕ-lek'tin ), A cell surface molecule involved in immune adhesion and cell trafficking. [L.
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. selectin: ( sĕ-lek'tin ), A cell surface molecule involved in immune adhesion and cell trafficking. [L.
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It does not bind to CHO cells Gene and protein expression of P-selectin and ICAM-1 were studied at 0.5, 1, 6, 12, (L-selectin), platelets (P-selectin), and endothelial cells (P- and E-selectin). intensity comparison of 28S expression versus each cytokine with P-Selectin and P-Selectin Glycoprotein Ligand 1 Mediate Rolling of Activated CD8+ T Cells METHODS:: Herein, we used a graft-versus-host disease (GvHD) model to study CD8 Inhibition of E-selectin had no effect on GvHD-induced CD8 av L Dieterich · 2011 · Citerat av 2 — teractions by increasing surface E-selectin. Manuscript.
P <0, 05, ** P <0, 01 och *** P <0, 001; NS, obetydlig.
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In addition to ICAM-1, the selectin family of adhesion molecules influences PMN– endothelial cell interaction. The selectins designated L-, P-, and E-selectin are a
E-selectin is a vascular adhesion molecule expressed mainly on endothelium, and its primary role is to facilitate leukocyte cell trafficking by recognizing ligand surface proteins.